POTENSI TANAMAN RAMBUTAN (NEPHELIUM LAPPACEUM) SEBAGAI OBAT HERBAL ANTI DIABETES
Abstract
Penyakit degeneratif seperti diabetes melitus sudah semakin sering terjadi. Hal ini disebabkan oleh gaya hidup yang tidak sehat seperti konsumsi makanan tinggi glukosa dan tidak diseimbangi oleh gerakan fisik yang mencukupi. Kadar gula darah yang terus tinggi akan menyebabkan komplikasi yang berujung dengan kematian. Tanaman rambutan (Nephelium lappaceum) menjadi salah satu alternatif yang dapat dijadikan obat herbal anti diabetes. Metabolit sekunder seperti flavonoid, kuarsetin dan tanin terbukti dapat menurunkan kadar gula darah. Review artikel ini bertujuan mengumpulkan informasi tentang potensi tanaman rambutan (Nephelium lappaceum) sebagai anti diabetes. Studi literatur dilakukan untuk mengumpulkan artikel-artikel dari Google dan Google Scholar. Artikel-artikel tersebut diunduh pada rentang tahun 2015-2024. Artikel-artikel yang dikaji tentang potensi tanaman rambutan (Nephelium lappaceum) sebagai anti diabetes. Dari hasil studi literatur diperoleh bahwa bagian biji, kulit dan daun tanaman rambutan (Nephelium lappaceum) memiliki potensi sebagai anti diabetes. Hal itu dibuktikan dari beberapa eksperimen yang dilakukan pada hewan percobaan. Senyawa yang terkandung adalah flavonoid, kuarsetin dan tanin.
References
Adeva-Andany, M. M., González-Lucán, M., Donapetry-García, C., Fernández-Fernández, C., & Ameneiros-Rodríguez, E. (2016). Glycogen metabolism in humans. BBA Clinical, 5, 85–100. https://doi.org/10.1016/j.bbacli.2016.02.001
Afandi, M. R., & Marpaung, F. R. (2019). Correlation Between Apoprotein B/Apoprotein a-I Ratio With Homa Ir Value (Homeostatic Model Assesment Insulin Resistance) in Type 2 Diabetes Mellitus. Journal of Vocational Health Studies, 3(2), 78. https://doi.org/10.20473/jvhs.v3.i2.2019.78-82
Alam, S., Sarker, M. M. R., Sultana, T. N., Chowdhury, M. N. R., Rashid, M. A., Chaity, N. I., Zhao, C., Xiao, J., Hafez, E. E., Khan, S. A., & Mohamed, I. N. (2022). Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development. Frontiers in Endocrinology, 13(February). https://doi.org/10.3389/fendo.2022.800714
Arora, K., Tomar, P. C., & Mohan, V. (2021). Diabetic neuropathy: an insight on the transition from synthetic drugs to herbal therapies. Journal of Diabetes and Metabolic Disorders, 20(2), 1773–1784. https://doi.org/10.1007/s40200-021-00830-2
Aschner, P., Muñoz, O. M., Girón, D., García, O. M., Fernández-Ávila, D., Casas, L. Á., Fernanda Bohórquez, L., Arango, C. M., Carvajal, L., Ramírez, D. A., Sarmiento, J. G., Colon, C. A., Fabián Correa, N., Alarcón, P., & Andrés Bustamante, Á. (2016). Guía de práctica clínica para la prevención, detección precoz, diagnóstico, manejo y seguimiento de la diabetes mellitus tipo 2 en adultos. Colombia Médica, 47. http://gpc.minsalud.gov.co/recursos/Documents/Gu
Awuchi, C. G., Echeta, C. K., & Igwe, V. S. (2020). Diabetes and the Nutrition and Diets for Its Prevention and Treatment: A Systematic Review and Dietetic Perspective. Health Sciences Research, 6(1).
Basak, S., Murmu, A., Matore, B. W., Roy, P. P., & Singh, J. (2024). Thiazolidinedione an auspicious scaffold as PPAR-γ agonist: its possible mechanism to Manoeuvre against insulin resistant diabetes mellitus. European Journal of Medicinal Chemistry Reports, 11(April), 100160. https://doi.org/10.1016/j.ejmcr.2024.100160
Bin Rakhis, S. A., AlDuwayhis, N. M., Aleid, N., AlBarrak, A. N., & Aloraini, A. A. (2022). Glycemic Control for Type 2 Diabetes Mellitus Patients: A Systematic Review. Cureus, 14(6), 6–13. https://doi.org/10.7759/cureus.26180
Bosetti, R., Tabatabai, L., Naufal, G., Menser, T., & Kash, B. (2021). Comprehensive cost-effectiveness of diabetes management for the underserved in the United States: A systematic review. PLoS ONE, 16(11 November), 1–19. https://doi.org/10.1371/journal.pone.0260139
Buttermore, E., Campanella, V., & Priefer, R. (2021). The increasing trend of Type 2 diabetes in youth: An overview. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 15(5), 102253. https://doi.org/10.1016/j.dsx.2021.102253
Chandel, N. S. (2021). Carbohydrate metabolism. Cold Spring Harbor Perspectives in Biology, 13(1), 1–15. https://doi.org/10.1101/cshperspect.a040568
Chiabchalard, A., & Nooron, N. (2015). Antihyperglycemic effects of Pandanus amaryllifolius Roxb. leaf extract. Pharmacognosy Magazine, 11(41), 117–122. https://doi.org/10.4103/0973-1296.149724
Dahlén, A. D., Dashi, G., Maslov, I., Attwood, M. M., Jonsson, J., Trukhan, V., & Schiöth, H. B. (2022). Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales. Frontiers in Pharmacology, 12(January), 1–16. https://doi.org/10.3389/fphar.2021.807548
Damian-Medina, K., Salinas-Moreno, Y., Milenkovic, D., Figueroa-Yanez, L., Marino-Marmolejo, E., Higuera-Ciapara, I., Vallejo-Cardona, A., & Lugo-Cervantes, E. (2020). In silico analysis of antidiabetic potential of phenolic compounds from blue corn (Zea mays L.) and black bean (Phaseolus vulgaris L.). Heliyon, 6, 1–13. https://doi.org/10.1016/j.heliyon.2020.e03632
Davoudi-Kiakalayeh, A., Mohammadi, R., Pourfathollah, A. A., Siery, Z., & Davoudi-Kiakalayeh, S. (2017). Alloimmunization in thalassemia patients: New insight for healthcare. International Journal of Preventive Medicine, 8, 1–7. https://doi.org/10.4103/ijpvm.IJPVM
Dirir, A. M., Daou, M., Yousef, A. F., & Yousef, L. F. (2022). A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes. In Phytochemistry Reviews (Vol. 21, Issue 4). Springer Netherlands. https://doi.org/10.1007/s11101-021-09773-1
Fokunang, C. N., Ndikum, V., Tabi, O. Y., Jiofack, R. B., Ngameni, B., Guedje, N. M., Tembe-Fokunang, E. A., Tomkins, P., Barkwan, S., Kechia, F., Asongalem, E., Ngoupayou, J., Torimiro, N. J., Gonsu, K. H., Sielinou, V., Ngadjui, B., Angwafor, I., Nkongmeneck, A., Abena, O. M., … Kamsu-Kom. (2011). Traditional medicine: Past, present and future research and development prospects and integration in the national health system of Cameroon. African Journal of Traditional, Complementary and Alternative Medicines, 8(3), 284–295. https://doi.org/10.4314/ajtcam.v8i3.65276
Gallwitz, B. (2019). Clinical use of DPP-4 inhibitors. Frontiers in Endocrinology, 10(JUN), 1–10. https://doi.org/10.3389/fendo.2019.00389
Gaonkar, V. P., & Hullatti, K. (2020). Indian Traditional medicinal plants as a source of potent Anti-diabetic agents: A Review. Journal of Diabetes and Metabolic Disorders, 19(2), 1895–1908. https://doi.org/10.1007/s40200-020-00628-8
Gong, X. xiao, Cao, L. hai, Ni, H. xia, Zang, Z. yan, & Chang, H. (2024). Chinese herbal medicine for the treatment of diabetic nephropathy: From clinical evidence to potential mechanisms. Journal of Ethnopharmacology, 330(2), 118179. https://doi.org/10.1016/j.jep.2024.118179
Gronda, E., Jessup, M., Iacoviello, M., Palazzuoli, A., & Napoli, C. (2020). Glucose metabolism in the kidney: Neurohormonal activation and heart failure development. Journal of the American Heart Association, 9(23). https://doi.org/10.1161/JAHA.120.018889
Guo, Y., Huang, Z., Sang, D., Gao, Q., & Li, Q. (2020). The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes. Frontiers in Bioengineering and Biotechnology, 8(September), 1–15. https://doi.org/10.3389/fbioe.2020.575442
Haddad, F., Dokmak, G., Bader, M., & Karaman, R. (2023). A Comprehensive Review on Weight Loss Associated with Anti-Diabetic Medications. Life, 13(4), 1–36. https://doi.org/10.3390/life13041012
Haghighatpanah, M., Nejad, A. S. M., Haghighatpanah, M., Thunga, G., & Mallayasamy, S. (2018). Factors that correlate with poor glycemic control in type 2 diabetes mellitus patients with complications. Osong Public Health and Research Perspectives, 9(4), 167–174. https://doi.org/10.24171/j.phrp.2018.9.4.05
Hsia, D. S., Grove, O., & Cefalu, W. T. (2017). An update on sodium-glucose co-transporter-2 inhibitors for the treatment of diabetes mellitus. Current Opinion in Endocrinology, Diabetes and Obesity, 24(1), 73–79. https://doi.org/10.1097/MED.0000000000000311
Jahurul, M. H. A., Azzatul, F. S., Sharifudin, M. S., Norliza, M. J., Hasmadi, M., Lee, J. S., Patricia, M., Jinap, S., Ramlah George, M. R., Firoz Khan, M., & Zaidul, I. S. M. (2020). Functional and nutritional properties of rambutan (Nephelium lappaceum L.) seed and its industrial application: A review. Trends in Food Science and Technology, 99(March), 367–374. https://doi.org/10.1016/j.tifs.2020.03.016
Jia, L., Shen, C., Lai, B., Huang, C., Zhao, N., Li, B., Zhang, Z., Cai, M., Yan, B., Liu, J., & Yang, S. (2024). Traditional Chinese medicine could play an important role in diabetes management: Commentary on “National Chinese medicine guideline for the prevention and treatment of diabetes in primary care (2022).” Journal of Diabetes, 16(4). https://doi.org/10.1111/1753-0407.13532
Jumani, D. K., & Patil, O. (2020). Erectile Dysfunction in Diabetes Mellitus: A Review. Journal of Diabetology. https://doi.org/10.4103/jod.jod
Karachaliou, F., Simatos, G., & Simatou, A. (2020). The Challenges in the Development of Diabetes Prevention and Care Models in Low-Income Settings. Frontiers in Endocrinology, 11(August), 1–9. https://doi.org/10.3389/fendo.2020.00518
Kasole, R., Martin, H. D., & Kimiywe, J. (2019). Traditional medicine and its role in the management of diabetes mellitus: “patients’’ and herbalists’ perspectives".” Evidence-Based Complementary and Alternative Medicine, 2019. https://doi.org/10.1155/2019/2835691
Katsarou, A., Gudbjörnsdottir, S., Rawshani, A., Dabelea, D., Bonifacio, E., Anderson, B. J., Jacobsen, L. M., Schatz, D. A., & Lernmark, A. (2017). Type 1 diabetes mellitus. Nature Reviews Disease Primers, 3(March), 1–18. https://doi.org/10.1038/nrdp.2017.16
Klein, S., Gastaldelli, A., Yki-Järvinen, H., & Scherer, P. E. (2022). Why does obesity cause diabetes? Cell Metabolism, 34(1), 11–20. https://doi.org/10.1016/j.cmet.2021.12.012
Lee, E. L., Richards, N., Harrison, J., & Barnes, J. (2022). Prevalence of Use of Traditional, Complementary and Alternative Medicine by the General Population: A Systematic Review of National Studies Published from 2010 to 2019. Drug Safety, 45(7), 713–735. https://doi.org/10.1007/s40264-022-01189-w
Lee, J., Noh, S., Lim, S., & Kim, B. (2021). Plant extracts for type 2 diabetes: From traditional medicine to modern drug discovery. Antioxidants, 10(1), 1–42. https://doi.org/10.3390/antiox10010081
Lee, S. H., Park, S. Y., & Choi, C. S. (2022). Insulin Resistance: From Mechanisms to Therapeutic Strategies. Diabetes and Metabolism Journal, 46(1), 15–37. https://doi.org/10.4093/DMJ.2021.0280
Lu, H., Xie, T., Wu, Q., Hu, Z., Luo, Y., & Luo, F. (2023). Alpha-Glucosidase Inhibitory Peptides: Sources, Preparations, Identifications, and Action Mechanisms. Nutrients, 15(19), 4267. https://doi.org/10.3390/nu15194267
Lv, W., Wang, X., Xu, Q., & Lu, W. (2019). Mechanisms and Characteristics of Sulfonylureas and Glinides. Current Topics in Medicinal Chemistry, 20(1), 37–56. https://doi.org/10.2174/1568026620666191224141617
Ma, Q., Guo, Y., Sun, L., & Zhuang, Y. (2017). Anti-diabetic effects of phenolic extract from rambutan peels (Nephelium lappaceum) in high-fat diet and streptozotocin-induced diabetic mice. Nutrients, 9(8). https://doi.org/10.3390/nu9080801
Malin, S. K., & Kashyap, S. R. (2014). Effects of metformin on weight loss: potential mechanisms. Current Opinion in Endocrinology & Diabetes and Obesity, 5. https://doi.org/10.1097/MED.0000000000000095
Mancusi, C., Izzo, R., di Gioia, G., Losi, M. A., Barbato, E., & Morisco, C. (2020). Insulin Resistance the Hinge Between Hypertension and Type 2 Diabetes. High Blood Pressure and Cardiovascular Prevention, 27(6), 515–526. https://doi.org/10.1007/s40292-020-00408-8
Megatsari, H., & Laksono, A. D. (2020). Food Consumption Habits and Diabetes Mellitus in Indonesia: An Ecological Study. December. https://doi.org/10.13140/RG.2.2.18308.96641
Mihailović, M., Dinić, S., Jovanović, J. A., Uskoković, A., Grdović, N., & Vidaković, M. (2021). The influence of plant extracts and phytoconstituents on antioxidant enzymes activity and gene expression in the prevention and treatment of impaired glucose homeostasis and diabetes complications. Antioxidants, 10(3), 1–25. https://doi.org/10.3390/antiox10030480
Mohebi, S., Parham, M., Sharifirad, G., & Gharlipour, Z. (2018). Social Support and Self ‑ Care Behavior Study. January, 1–6. https://doi.org/10.4103/jehp.jehp
Mohiuddin, G. S., Palaian, S., Shankar, P. R., Sam, K. G., & Kumar, M. (2019). Uncommon Side Effects of Commonly Used Anti-Diabetics: Time To Monitor Them | International Journal of Pharmaceutical Sciences and Research. International Journal of Pharmaceutical Sciences and Research, 10(9), 4145–4148. https://doi.org/10.13040/IJPSR.0975-8232.10(9).4145-48
Muccilli, V., Cardullo, N., Spatafora, C., Cunsolo, V., & Tringali, C. (2017). α-Glucosidase inhibition and antioxidant activity of an oenological commercial tannin. Extraction, fractionation and analysis by HPLC/ESI-MS/MS and 1H NMR. Food Chemistry, 215, 50–60. https://doi.org/10.1016/j.foodchem.2016.07.136
Muhtadi, M., Haryoto, H., Sujono, T. A., & Suhendi, A. (2016). Antidiabetic and antihypercholesterolemia activities of rambutan (Nephelium lappaceum L.) and durian (Durio zibethinus Murr.) fruit peel extracts. Journal of Applied Pharmaceutical Science, 6(4), 2231–3354. https://doi.org/10.7324/JAPS.2016.60427
Muhtadi, Primarianti, A. U., & Sujono, T. A. (2015). Antidiabetic Activity of Durian (Durio Zibethinus Murr.) and Rambutan (Nephelium Lappaceum L.) Fruit Peels in Alloxan Diabetic Rats. Procedia Food Science, 3, 255–261. https://doi.org/10.1016/j.profoo.2015.01.028
Mujtahid, M. (2020). Blood glucose regulating hormones and their physiological and biochemical roles. Journal of Experimental Sciences, 11, 44–49. https://doi.org/10.25081/jes.2020.v11.6570
Nasim, N., Sandeep, I. S., & Mohanty, S. (2022). Plant-derived natural products for drug discovery: current approaches and prospects. Nucleus (India), 65(3), 399–411. https://doi.org/10.1007/s13237-022-00405-3
Neoh, G. K. S., Tan, X., Chen, S., Roura, E., Dong, X., & Gilbert, R. G. (2024). Glycogen metabolism and structure: A review. Carbohydrate Polymers, 346(August), 122631. https://doi.org/10.1016/j.carbpol.2024.122631
Niisato, N., & Marunaka, Y. (2023). Therapeutic potential of multifunctional myricetin for treatment of type 2 diabetes mellitus. Frontiers in Nutrition, 10(May), 1–6. https://doi.org/10.3389/fnut.2023.1175660
Ogihara, T., Mizoi, K., & Ishii-Watabe, A. (2023). Pharmacokinetics of Biopharmaceuticals: Their Critical Role in Molecular Design. Biomedicines, 11(5). https://doi.org/10.3390/biomedicines11051456
Ong, K. L., Stafford, L. K., McLaughlin, S. A., Boyko, E. J., Vollset, S. E., Smith, A. E., Dalton, B. E., Duprey, J., Cruz, J. A., Hagins, H., Lindstedt, P. A., Aali, A., Abate, Y. H., Abate, M. D., Abbasian, M., Abbasi-Kangevari, Z., Abbasi-Kangevari, M., ElHafeez, S. A., Abd-Rabu, R., … Vos, T. (2023). Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet, 402(10397), 203–234. https://doi.org/10.1016/S0140-6736(23)01301-6
Ozawa, S., Shankar, R., Leopold, C., & Orubu, S. (2019). Access to medicines through health systems in low-and middle-income countries. Health Policy and Planning, 34. https://doi.org/10.1093/heapol/czz119
Powers, M. A., Bardsley, J. K., Cypress, M., Funnell, M. M., Harms, D., Hess-Fischl, A., Hooks, B., Isaacs, D., Mandel, E. D., Maryniuk, M. D., Norton, A., Rinker, J., Siminerio, L. M., & Uelmen, S. (2020). Diabetes Self-management Education and Support in Adults With Type 2 Diabetes: A Consensus Report of the American Diabetes Association, the Association of Diabetes Care & Education Specialists, the Academy of Nutrition and Dietetics, the American Academy . Diabetes Educator, 46(4), 350–369. https://doi.org/10.1177/0145721720930959
Rahman, M. S., Hossain, K. S., Das, S., Kundu, S., Adegoke, E. O., Rahman, M. A., Hannan, M. A., Uddin, M. J., & Pang, M. G. (2021). Role of insulin in health and disease: An update. International Journal of Molecular Sciences, 22(12), 1–19. https://doi.org/10.3390/ijms22126403
Ramkisson, S., Pillay, B. J., & Sibanda, W. (2017). Social support and coping in adults with type 2 diabetes. African Journal of Primary Health Care and Family Medicine, 9(1), 1–8. https://doi.org/10.4102/phcfm.v9i1.1405
Rao, G., & Jensen, E. T. (2020). Type 2 Diabetes in Youth. Global Pediatric Health, 7. https://doi.org/10.1177/2333794X20981343
Rena, G., Hardie, D. G., & Pearson, E. R. (2017). The mechanisms of action of metformin. 1577–1585. https://doi.org/10.1007/s00125-017-4342-z
Saberzadeh-Ardestani, B., Karamzadeh, R., Basiri, M., Hajizadeh-Saffar, E., Farhadi, A., Shapiro, A. M. J., Tahamtani, Y., & Baharvand, H. (2018). Type 1 diabetes mellitus: Cellular and molecular pathophysiology at a glance. Cell Journal, 20(3), 294–301. https://doi.org/10.22074/cellj.2018.5513
Salehi, B., Ata, A., Kumar, N. V. A., Sharopov, F., Ramírez-Alarcón, K., Ruiz-Ortega, A., Ayatollahi, S. A., Fokou, P. V. T., Kobarfard, F., Zakaria, Z. A., Iriti, M., Taheri, Y., Martorell, M., Sureda, A., Setzer, W. N., Durazzo, A., Lucarini, M., Santini, A., Capasso, R., … Sharifi-Rad, J. (2019). Antidiabetic potential of medicinal plants and their active components. In Biomolecules (Vol. 9, Issue 10). https://doi.org/10.3390/biom9100551
Sampath Kumar, A., Maiya, A. G., Shastry, B. A., Vaishali, K., Ravishankar, N., Hazari, A., Gundmi, S., & Jadhav, R. (2019). Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis. Annals of Physical and Rehabilitation Medicine, 62(2), 98–103. https://doi.org/10.1016/j.rehab.2018.11.001
Shaito, A., Thuan, D. T. B., Phu, H. T., Nguyen, T. H. D., Hasan, H., Halabi, S., Abdelhady, S., Nasrallah, G. K., Eid, A. H., & Pintus, G. (2020). Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety. Frontiers in Pharmacology, 11(April), 1–32. https://doi.org/10.3389/fphar.2020.00422
Sharma, K., Akre, S., Chakole, S., & Wanjari, M. B. (2022). Stress-Induced Diabetes: A Review. Cureus, 14(9), 1–6. https://doi.org/10.7759/cureus.29142
Street, M. E., Moghetti, P., & Chiarelli, F. (2023). The Multiple Functions of Insulin Put into Perspective: From Growth to Metabolism, and from Well-Being to Disease. International Journal of Molecular Sciences, 24(1), 14–16. https://doi.org/10.3390/ijms24010200
Suhendi, A., & Muhtadi, M. (2015). Potential Activity of Rambutan (Nepheliumlappaceum L.) Fruit Peel Extract as Antidiabetic and Antihypercholesterolemia. Icetea, 1(October), 20–23. https://doi.org/10.13140/RG.2.1.2424.9042
Suliska, N., Maryam, S., & Leni, N. (2020). Efek Antihiperglikemia Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.) pada Mencit Jantan (Swiss Webster) dengan Metode Induksi Glukosa. Medicine and Health, 2(6), 128–137.
Susilawati, E., Suwendar, & Desianti, G. (2017). Susilawati: Aktivitas Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.) sebagai Antidiabetes pada Mencit yang Diinduksi Aloksan. Jurnal Farmasi Galenika, 4.
Syamsurizal. (2018). Type-2 Diabetes Mellitus of Degenerative Disease. Bioscience, 2(1). https://doi.org/10.24036/02018219980-0-00
Tan, S. Y., Mei Wong, J. L., Sim, Y. J., Wong, S. S., Mohamed Elhassan, S. A., Tan, S. H., Ling Lim, G. P., Rong Tay, N. W., Annan, N. C., Bhattamisra, S. K., & Candasamy, M. (2019). Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13(1), 364–372. https://doi.org/10.1016/j.dsx.2018.10.008
Tola, S. M., Faradz, S. M. H., Utomo, A. R. H., & Mustofa, S. (2024). Pharmacodynamic of Metformin in Type 2 Diabetes Mellitus Patients : Review of the PRKAA2 and SLC22A3 Genes. Jurnal Kedokteran dan Kesehatan: Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya, 11(3), 381–393. https://doi.org/10.32539/JKK.V11I3.462
Tran, N., Pham, B., & Le, L. (2020). Bioactive compounds in anti-diabetic plants: From herbal medicine to modern drug discovery. Biology, 9(9), 1–31. https://doi.org/10.3390/biology9090252
Unnikrishnan, A. G., Kalra, S., Purandare, V., & Vasnawala, H. (2018). Genital infections with sodium glucose cotransporter-2 inhibitors: Occurrence and management in patients with type 2 diabetes mellitus. Indian Journal of Endocrinology and Metabolism, 22(6), 837–842. https://doi.org/10.4103/ijem.IJEM_159_17
Unuofin, J. O., & Lebelo, S. L. (2020). Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review. Oxidative Medicine and Cellular Longevity, 2020. https://doi.org/10.1155/2020/1356893
Vargas-Sánchez, K., Garay-Jaramillo, E., & González-Reyes, R. E. (2019). Effects of moringa oleifera on glycaemia and insulin levels: A review of animal and human studies. Nutrients, 11(12), 1–19. https://doi.org/10.3390/nu11122907
Widyawati, T., Syahputra, R. A., Syarifah, S., & Sumantri, I. B. (2023). Analysis of Antidiabetic Activity of Squalene via In Silico and In Vivo Assay. Molecules, 28(9), 1–14. https://doi.org/10.3390/molecules28093783
Wolosowicz, M., Prokopiuk, S., & Kaminski, T. W. (2022). Recent Advances in the Treatment of Insulin Resistance Targeting Molecular and Metabolic Pathways: Fighting a Losing Battle? Medicina (Lithuania), 58(4). https://doi.org/10.3390/medicina58040472
Wondmkun, Y. T. (2020). Obesity, insulin resistance, and type 2 diabetes: Associations and therapeutic implications. Diabetes, Metabolic Syndrome and Obesity, 13, 3611–3616. https://doi.org/10.2147/DMSO.S275898
Xu, Z., Wang, S., Li, D., Wang, Y., Wang, S., & Guo, K. (2022). Exercise/Physical Activity in Individuals with Type 2 Diabetes from the American College of Sports Medicine: Interpretation and Clinical Significance. In Chinese General Practice (Vol. 25, Issue 25). https://doi.org/10.12114/j.issn.1007-9572.2022.0353
Yang, M., Hu, B., & Zhang, Q. (2026). Analysis of Factors Influencing Subjective Well-Being in Young and Middle-Aged Patients Undergoing Maintenance Hemodialysis. British Journal of Hospital Medicine, 87, 1–9. https://doi.org/10.31083/BJHM50724
Yuda, A. A. G. P., Rusli, R., & Ibrahim, A. (2015). Kandungan Metabolit Sekunder Dan Efek Penurunan Glukosa Darah Ekstrak Biji Rambutan (Nephelium Lappaceum L) Pada Mencit (Mus musculus). Jurnal Sains dan Kesehatan, 1. http://digilib.unila.ac.id/4949/15/BAB II.pdf
Zhao, X., An, X., Yang, C., Sun, W., Ji, H., & Lian, F. (2023). The crucial role and mechanism of insulin resistance in metabolic disease. Frontiers in Endocrinology, 14(March). https://doi.org/10.3389/fendo.2023.1149239
Zheng, Z., Zong, Y., Ma, Y., & Tian, Y. (2024). Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Signal Transduction and Targeted Therapy, July. https://doi.org/10.1038/s41392-024-01931-z
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